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(±)-Homocrepidine A, a Pair of Anti-inflammatory Enantiomeric Octahydroindolizine Alkaloid Dimers from Dendrobium crepidatum 期刊论文

编号：

E7D607A735E640B723E2A59A5A3A0873
作者：

Hu, Yang#^[1]Zhang, Chaofeng(张朝凤)*^[1]Zhao, Xin^[1];Wang, Yue^[1];Feng, Deqiang^[2];Zhang, Mian^[1];Xie, Haifeng^[3];
语种：

英文
期刊：

JOURNAL OF NATURAL PRODUCTS ISSN：0163-3864 2016 年 79 卷 1 期 (252 - 256) ; JAN
收录：
摘要：

A pair of racemic indolizidine enantiomers, (+/-)-homocrepidine A (1), and a piperidine derivative, homocrepidine B (2), were isolated from Dendrobium crepidatum along with the known alkaloid crepidine (3). The racemic mixture of 1 was separated into a pair of enantiomers, (+)-1 and (-)-1, by HPLC using a chiral chromatographic substrate, which represents the first successful example of resolving indolizidine racemic mixtures. The absolute configurations of (+)-1 and (-)-1 were assigned from single-crystal X-ray diffraction data. The evaluation of anti-inflammatory activity with LPS-induced RAW 264.7 macrophages revealed that (+)-1 strongly inhibited the production of nitric oxide (IC50, 3.6 mu M) and significantly decreased the expression of inducible nitric oxide synthase, while (-)-1 and (+/-)-1 only had moderate inhibitory effects (IC50, 22.8 and 14.7 mu M). Compound 2 showed moderate anti-inflammatory activity (IC50, 27.6 mu M).
推荐引用方式
GB/T 7714：

Hu Yang,Zhang Chaofeng,Zhao Xin, et al. (±)-Homocrepidine A, a Pair of Anti-inflammatory Enantiomeric Octahydroindolizine Alkaloid Dimers from Dendrobium crepidatum [J].JOURNAL OF NATURAL PRODUCTS,2016,79(1):252-256.
APA：

Hu Yang,Zhang Chaofeng,Zhao Xin,Wang Yue,&Xie Haifeng.(2016).(±)-Homocrepidine A, a Pair of Anti-inflammatory Enantiomeric Octahydroindolizine Alkaloid Dimers from Dendrobium crepidatum .JOURNAL OF NATURAL PRODUCTS,79(1):252-256.
MLA：

Hu Yang, et al. "(±)-Homocrepidine A, a Pair of Anti-inflammatory Enantiomeric Octahydroindolizine Alkaloid Dimers from Dendrobium crepidatum" .JOURNAL OF NATURAL PRODUCTS 79,1(2016):252-256.
入库时间：

2024/7/16 2:09:00
更新时间：

2024/7/16 2:09:00
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