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Molecular characterization of bat HBV and identification of HDV co-infection in Yunnan, China 期刊论文

编号：

F141DC815536F7ECCCABFB2A801E3C49
作者：

Kui, Yushan#^[1]Wang, Jiale^[1];Ning, Yuting^[1];Hou, Yutong^[1];Deng, Lulu^[1];Wang, Binghui^[2];Li, Wen*^[3]Xia, Xueshan(夏雪山)*^[1,2]
语种：

英文
期刊：

FRONTIERS IN MICROBIOLOGY ISSN：1664-302X 2026 年 17 卷 ; FEB 10
收录：
关键词：

bat co-infection hepatitis B virus hepatitis D virus phylogenetic analysis
摘要：

Background Bats are natural reservoirs for Orthohepadnaviruses, but the diversity and evolution of bat hepatitis B viruses (BtHBVs) and their co-infection with bat hepatitis D virus (BtHDV) in China remain poorly understood.Methods In a molecular survey of bats from Yunnan Province, we detected BtHBV in 36.86% (129/350) of the samples, showing a notably high prevalence in Hipposideros pomona (41.75%). BtHDV co-infection was observed in 1.14% of BtHBV-positive bats.Results Genomic analysis of 18 BtHBV isolates revealed that all belong to the bat-specific Orthohepadnavirus Lineage V (BtHBV-7), yet exhibit measurable genetic divergence. We also characterized a highly divergent bat HDV strain, BtHDV-YNNJ49, which clusters within a distinct bat-associated deltavirus lineage but displays substantial genetic divergence from its closest relative, underscoring diversity within this lineage.Conclusions Collectively, our findings suggest that bats in Yunnan, particularly H. pomona, may act as natural hosts for both BtHBV and BtHDV. The identification of this divergent BtHDV strain expands our understanding of the genetic diversity and evolution of deltaviruses.
推荐引用方式
GB/T 7714：

Kui Yushan,Wang Jiale,Ning Yuting, et al. Molecular characterization of bat HBV and identification of HDV co-infection in Yunnan, China [J].FRONTIERS IN MICROBIOLOGY,2026,17.
APA：

Kui Yushan,Wang Jiale,Ning Yuting,Hou Yutong,&Xia Xueshan.(2026).Molecular characterization of bat HBV and identification of HDV co-infection in Yunnan, China .FRONTIERS IN MICROBIOLOGY,17.
MLA：

Kui Yushan, et al. "Molecular characterization of bat HBV and identification of HDV co-infection in Yunnan, China" .FRONTIERS IN MICROBIOLOGY 17(2026).
入库时间：

2026/3/9 21:58:01
更新时间：

2026/3/9 21:58:01

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