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tBHQ Suppresses Osteoclastic Resorption in Xenogeneic-Treated Dentin Matrix-Based Scaffolds 期刊论文

编号：

a1d71ecc-109c-41a3-9d96-72614c416dd0
作者：

Sun, Jingjing#^[1,2]Li, Jie#^[1,3]Li, Hui^[1,2];Yang, Hefeng(杨禾丰)^[4]Chen, Jinlong^[1,2];Yang, Bo(杨博)^[1,2]Huo, Fangjun^[1];Guo, Weihua(郭维华)*^[1,5]Tian, Weidong(田卫东)*^[1,2]
语种：

英文
期刊：

ADVANCED HEALTHCARE MATERIALS ISSN：2192-2640 2017 年 6 卷 18 期 ; SEP 20
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关键词：

extracellular matrix (ECM) osteoclastic resorption tert-butylhydroquinone (tBHQ) treated dentin matrix (TDM)-based scaffolds
摘要：

Extracellularmatrix (ECM)-based scaffolds are important for their potential therapeutic application. Treated dentin matrix (TDM), a kind of ECM, seeded with allogeneic dental follicle stem cells (TDM/aDFC) provides a suitable inductive microenvironment for tooth root regeneration. Considering the limited sources, xenogeneic TDM (xTDM) is a possible alternative to allogeneic TDM; however, xTDM-based scaffold presents severe osteolysis and resorption lacunae causing regenerated tooth root failure. Immune response-induced excessive osteoclastogenesis plays a critical role in xenogeneic scaffold osteolysis and resorption. The impact of antioxidant, tert-butylhydroquinone (tBHQ), on xTDM/aDFCs-induced osteoclastogenesis and osteoclastic resorption in vivo and in vitro are investigated. tBHQ upregulates heme oxygenase-1 release and downregulates high mobility group box 1 mRNA expression. mRNA expression of other osteoclast-related genes including nuclear factor-kappa Bp65, receptor activator of nuclear factor kappa-B, nuclear factor of activated T-cells cytoplasmic 1, cathepsin K, and integrin 3, also decreases significantly. Furthermore, tBHQ-treated xTDM/aDFCs scaffolds implanted into rhesus macaques show reduced osteolysis and osteoclastic resorption by microcomputed tomography and tartrate-resistant acid phosphatase staining. tBHQ-induced suppression of xTDM/aDFC-induced osteoclastogenesis and osteoclastic resorption presents a new strategy for the regeneration of biological tooth root and could be applied to the regeneration of other complex tissues and organs.
推荐引用方式
GB/T 7714：

Sun Jingjing,Li Jie,Li Hui, et al. tBHQ Suppresses Osteoclastic Resorption in Xenogeneic-Treated Dentin Matrix-Based Scaffolds [J].ADVANCED HEALTHCARE MATERIALS,2017,6(18).
APA：

Sun Jingjing,Li Jie,Li Hui,Yang Hefeng,&Tian Weidong.(2017).tBHQ Suppresses Osteoclastic Resorption in Xenogeneic-Treated Dentin Matrix-Based Scaffolds .ADVANCED HEALTHCARE MATERIALS,6(18).
MLA：

Sun Jingjing, et al. "tBHQ Suppresses Osteoclastic Resorption in Xenogeneic-Treated Dentin Matrix-Based Scaffolds" .ADVANCED HEALTHCARE MATERIALS 6,18(2017).
入库时间：

2020/4/13 14:43:41
更新时间：

2020/4/13 14:43:41
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