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Efficacy and safety of nimotuzumab in addition to radiotherapy and temozolomide for cerebral glioblastoma: a phase II multicenter clinical trial 期刊论文

编号：

deda7a0e-9d80-49d1-b67b-282b50a4dcb7
作者：

Du, XiaoJing(杜晓京)#^[1,2,3]Li, XianMing(李先明)^[4]Cai, LinBo(蔡林波)^[5]Sun, JianCong(孙建聪)^[6]Wang, SiYang(王思阳)^[7]Wang, XiCheng^[8];Pang, XiaoLin^[1,2,3];Deng, MeiLing(邓美玲)^[1,2,3]Chen, FangFang^[1,2,3];Wang, ZhiQiang(王志强)^[1,2,3]Chen, FuRong^[2,3,9];Zhang, HongHong^[1,2,3];Wang, HuiYun(王辉云)^[2,3,9]Piedra, Patricia^[10];Chen, ZhongPing(陈忠平)^[2,3,11]Lin, Jun^[12];Wu, ShaoXiong(吴少雄)*^[1,2,3]
语种：

英文
期刊：

JOURNAL OF CANCER ISSN：1837-9664 2019 年 10 卷 14 期 (3214 - 3223)
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关键词：

glioblastoma radiotherapy temozolomide nimotuzumab epidermal growth factor receptor O (6)-methylquanine DNA methyl-tranferase (MGMT)
摘要：

Background: Nimotuzumab is a humanized anti-epidermal growth factor receptor (EGFR) antibody that has shown preclinical and clinical anticancer activity in cerebral glioblastoma multiforme (GBM). We conducted a phase II, single-arm, multicenter clinical trial to evaluate the benefit of adding nimotuzumab to current standard chemo-radiotherapy for patients with GBM with positive EGFR expression.
Methods: Newly diagnosed patients with histologically proven single supratentorial GBM and epidermal growth factor receptor (EGFR) positive expressions were recruited. All patients were treated with nimotuzumab, administered once a week intravenously for 6 weeks in addition to radiotherapy with concomitant and adjuvant temozolomide after surgery. The primary endpoints were overall survival (OS) and progression-free survival (PFS). Secondary objectives included objective response rate (ORR) and toxicity.
Results: A total of 39 patients were enrolled and 36 patients were evaluated for efficacy. The ORR at the end of RT was 72.2%. Median OS and PFS were 24.5 and 11.9 months. The 1-year OS and PFS rates were 83.3% and 49.3%. The 2-year OS and PFS rates were 51.1% and 29.0%. O (6)-methylquanine DNA methyl-tranferase (MGMT) expression is known to affect the efficacy of chemotherapy and status of its expression is examined. No significant correlation between treatment outcomes and MGMT status was found. Most frequent treatment-related toxicities were mild to moderate and included constipation, anorexia, fatigue, nausea, vomiting, and leucopenia.
Conclusions: Our study show that nimotuzumab in addition to standard treatment is well tolerable and has increased survival in newly diagnosed GBM patients with EGFR positive expression.
推荐引用方式
GB/T 7714：

Du Xiao-Jing,Li Xian-Ming,Cai Lin-Bo, et al. Efficacy and safety of nimotuzumab in addition to radiotherapy and temozolomide for cerebral glioblastoma: a phase II multicenter clinical trial [J].JOURNAL OF CANCER,2019,10(14):3214-3223.
APA：

Du Xiao-Jing,Li Xian-Ming,Cai Lin-Bo,Sun Jian-Cong,&Wu Shao-Xiong.(2019).Efficacy and safety of nimotuzumab in addition to radiotherapy and temozolomide for cerebral glioblastoma: a phase II multicenter clinical trial .JOURNAL OF CANCER,10(14):3214-3223.
MLA：

Du Xiao-Jing, et al. "Efficacy and safety of nimotuzumab in addition to radiotherapy and temozolomide for cerebral glioblastoma: a phase II multicenter clinical trial" .JOURNAL OF CANCER 10,14(2019):3214-3223.
入库时间：

2021/10/18 14:38:55
更新时间：

2021/10/18 14:38:55
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